DISTRIBUTION



The drug that comes directly from digitalis Purpurea is digitoxin

Digitoxin metabolism can be accelerated by:

-Barbituates
-Phenylbutazone
-Diphenylhydantoin


The heart microsomes, contained within the individual myocardial cells, appear to have the highest concentration of glycosides. Even though the heart microsomes appear to contain the highest levels, glycosides distribute evenly throughout the body.

Digitoxin is found in high concentrations in the:

-Liver
-Gallbladder
-Small and large intestine
-The right and left heart ventricles contain nearly twice the concentration as that of the atria.

Glycosides are not distributed in fat tissue. This is important when taking into account tratement of overweight patients. Digitoxin can also pass easily through the placenta.

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